Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease - Parenchima

Project Summary

Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease - Parenchima is COST Action CA16103.

The rising prevalence of Chronic Kidney Disease (CKD) poses a major public health challenge affecting >10% of the population. But the field has not seen a truly new therapy in over 15 years, and an alarming number of large recent CKD progression trials have failed. In order to overcome this challenge, there is an urgent need for better biomarkers to identify patients that are at risk of progression, or are likely to respond to candidate therapeutics. Magnetic Resonance Imaging (MRI) biomarkers have shown a high potential to help fill this gap as they are non-invasive and sensitive to CKD pathophysiology.

Despite their potential, renal MRI biomarkers are today underused in research and in clinical practice due to the need for dedicated in-house expertise and development. Transferring solutions to other centres is therefore a challenge, and this leads to a significant duplication of efforts, a lack of standardisation in the methods, and difficulties in comparing results between centres. This also limits commercial exploitation, and hinders the set-up of multi-centre trials or translation into clinical practice.

The overall aim of PARENCHIMA is to eliminate the main barriers to the broader study, commercial exploitation and clinical use of renal MRI biomarkers. PARENCHIMA will coordinate the research of leading European groups in this area to: (1) improve the reproducibility and standardisation of renal MRI biomarkers; (2) increase their availability by developing an open-access toolbox with software and data; (3) demonstrate biological validity and clinical utility in a prospective multicentre clinical study.

Project Team

The project team comprises members from 22 European countries. Professor Lončarić is a member of the Management Committee representing Croatia.

For more information please visit the official COST Action CA16103 page.